Using the HIV virus against itself

The HIV virus is known to be able to dock on the CD4 receptor of CD4 T cells via its GP120, infecting the CD4 T cells in the process.

I doodled out a possible therapeutic strategy, using the HIV virus against itself. Now, RNAi technology is improving, and it's possible to produce permanent cell-lines producing siRNA to knock down genes. Using genetic engineering techniques, siRNA inserts that target HIV virus genes can be designed. By genetic engineering, this therapeutic version of the HIV virus based on the principle of retroviral RNAi can be designed, with the harmful genes deleted.

What happens is that this therapeutic HIV virus is still able to infect CD4 T cells, BUT it can enable the CD4 T cells to knock down the genes of the pathogenic and harmful HIV virus. It can knock down the expression of harmful HIV virus genes in infected CD4 T cells and boost the RNAi defense of uninfected CD4 T cells against the HIV virus. It's a form of retroviral gene therapy cum defense against the pathogenic HIV virus.

Citations

Retroviral RNAi http://www.imgenex.com/rnai_list.php?id=26