Multidrug resistance is a barrier to the treatment of cancer with chemotherapeutic strategies (Gottesman et al, 2002). P-glycoprotein transporters are responsible for the efflux of drugs from the cancer cells. A number of inhibitors have been designed for the multidrug resistance protein, for instance, the MDR-1 P-glycoprotein. These inhibitors will be added into the cocktail containing an arsenal anti-cancer drug to ensure a move effective treatment. However, side effects should be anticipated considering the fact that MDR drug pumps have a physiological role in our livers and kidneys.
Citations
1) Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer. 2002 Jan;2(1):48-58.
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